Clinical:Hormone Replacement Therapy

Hormone replacement therapy is the "therapeutic use of hormones to alleviate the effects of hormone deficiency."^[1] Hormone replacement therapy includes estrogen replacement therapy.

Estrogen replacement therapy

There is increased risk of harm if estrogen replacement therapy is started later in life according to the HERS^[2] and Women’s Health Initiative (WHI) ^[3][4] randomized controlled trials.

There is conflicting evidence regarding risk of cardiovascular disease among women who start hormone replacement therapy soon after menopause.^[5][6]

References

1. ↑ Anonymous, (2009) Hormone Replacement Therapy (English). Medical Subject Headings. U.S. National Library of Medicine.
2. ↑ Hulley, S et. al. "Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group." JAMA : the journal of the American Medical Association 280 (1998): 605-13 - Abstract
3. ↑ Rossouw, Jacques E et. al. "Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial." JAMA : the journal of the American Medical Association 288 (2002): 321-33 - Abstract
4. ↑ Anderson, Garnet L et. al. "Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial." JAMA : the journal of the American Medical Association 291 (2004): 1701-12 - Abstract
5. ↑ Prentice, Ross L et. al. "Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause." American journal of epidemiology 170 (2009): 12-23 - Abstract
6. ↑ Rossouw, Jacques E et. al. "Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause." JAMA : the journal of the American Medical Association 297 (2007): 1465-77 - Abstract