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Clinical:Parkinson's disease gene and risk factor database
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This database catalogues a number of genes and environmental risk factors that have been implicated in Parkinson's disease. Environmental risk factors include the mitochondrial toxins MPTP, rotenone and paraquat, while viral risk factors include influenza, which is thought to be responsible for encephalitis lethargica following the 1918 flu pandemic. Interestingly,as also suggested by others, genes and risk factors are in some cases related.The Kegg pathways and signalling networks traced out by the genetic risk factors can be seen at this page. Many are involved in drug and toxin metabolism , or in mitochondrial respiration, the target of pesticide toxicity, while others are related to the immune system and to pathogen entry pathways. Genes and risk factors seem to fit together in these networks, which may help in our understanding of this complex disease.
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